Astonlee Veterinary Hospital and Surgery
Tickford Street, Newport Pagnell, Milton Keynes, Buckinghamshire, MK16 9BA United Kingdom
Tel: 01908 611637
D. S. Edwards, , W. E. Henley, E. R. Ely and J. L. N. Wood
Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
Following concerns raised over the safety of canine vaccines, an epidemiological investigation was conducted to evaluate the evidence for a temporal association between vaccination and ill-health in dogs. The owners of a randomly selected population of dogs were sent 9055 postal questionnaires, 4040 of which were returned. No temporal association was found between vaccination and ill-health in dogs after adjusting for potential confounders, such as age.
However, reliable inferences from non-significant test results are limited and so equivalence-testing methods were also used to make informative inferences. Results demonstrated that recent vaccination (<3 months) does not increase signs of ill-health by more than 0.5% and may actually decrease it by as much as 5%. This general approach should be used in all field studies of vaccine safety.
Astonlee Veterinary Hospital and Surgery
Tickford Street, Newport Pagnell, Milton Keynes, Buckinghamshire, MK16 9BA United Kingdom
Tel: 01908 611637
Tickford Street, Newport Pagnell, Milton Keynes, Buckinghamshire, MK16 9BA United Kingdom
Tel: 01908 611637
Vaccinations
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Vaccination and ill-health in dogs: a lack of temporal association and evidence of equivalenceD. S. Edwards, , W. E. Henley, E. R. Ely and J. L. N. Wood
Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK
Following concerns raised over the safety of canine vaccines, an epidemiological investigation was conducted to evaluate the evidence for a temporal association between vaccination and ill-health in dogs. The owners of a randomly selected population of dogs were sent 9055 postal questionnaires, 4040 of which were returned. No temporal association was found between vaccination and ill-health in dogs after adjusting for potential confounders, such as age.
However, reliable inferences from non-significant test results are limited and so equivalence-testing methods were also used to make informative inferences. Results demonstrated that recent vaccination (<3 months) does not increase signs of ill-health by more than 0.5% and may actually decrease it by as much as 5%. This general approach should be used in all field studies of vaccine safety.
Astonlee Veterinary Hospital and Surgery
Tickford Street, Newport Pagnell, Milton Keynes, Buckinghamshire, MK16 9BA United Kingdom
Tel: 01908 611637
 
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